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Springer Nature1
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Archives of Toxicology1
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20261
Max Spaenig results 1 · Newest (Page 1/1, per page 25)
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Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazinesNARA Subscribed
Archives of Toxicology · 2026 · Vol. 100 · Issue 5 · Springer
Abishek Laxmanan Ravi Shankar; Jenny Irwan; Max Spaenig; Maxim Carlier; Tanja Hansen; Nicole Zumbülte; Barira Islam; Patrik Lundquist; Richard Svensson; Todd Gouin; Timo Hamers; Sylvia E. Escher
Bottom-up in vitro ADME parameterized PBK models play a vital role in Next Generation Risk Assessment (NGRA), which evaluates the toxicological hazards of compounds through New Approach Methods (NAMs). The ZeroPM project, funded by the EU under Horizon 2020, develops strategies to prioritize persistent (P) and mobile (M) compounds for regulatory measures based on exposure levels and toxicological properties. This study develop...
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