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Springer Nature1
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Angiogenesis1
Publication Year
20261
Maximillian Gerhardt results 1 · Newest (Page 1/1, per page 25)
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Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesisNARA Subscribed
Angiogenesis · 2026 · Vol. 29 · Issue 4 · Springer
Yi Lu; Alice Reschigna; Franz Kynast; Zhuo Yang; Maximillian Gerhardt; Pavel Kielkowski; Siegfried Priglinger; Martin Biel; Stylianos Michalakis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), yet the molecular regulators coordinating vascular and immune components remain incompletely defined. Here, we investigated the role of the endolysosomal cation channel, two-pore channel 2 (TPC2) in choroidal angiogenesis. Loss of TPC2 in mice markedly reduced ex vivo choroidal sprouting, while pharmacologica...
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