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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
This study examines the 3D attributes of submesoscale eddies identified over a 12-month period within the Western Pacific Ocean. Composite parameters of cyclonic submesoscale eddies (CSMEs) occurring within and away from the Kuroshio Current system are compared and analyzed for their surface and subsurface features, as well as the seasonality of their core properties. Within the Kuroshio Current (KC) region, CSMEs are faster,...
Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Rice consumption is a pathway for human exposure to toxic elements. Although rice is a major staple in the Kingdom of Saudi Arabia (KSA) there is limited published data about its toxic element composition. Both imported and locally grown Hassawi rice in Saudi Arabia were collected, digested then analysed by HPLC-ICP-MS for inorganic arsenic (i-As) and by ICP-MS for As, Cd, Pb and Hg. Of these toxic elements, i-As was present a...
Feeding Ration Impacts Larval Pimephales Promelas 7-Day Subchronic Growth Endpoint: Case Study with Perfluorooctanesulfonic AcidNARA Subscribed
The larval fathead minnow, Pimephales promelas , 7-day subchronic survival and growth standard toxicity test method is commonly used for research and regulatory testing of effluents and compounds, including emerging contaminants such as Perfluorooctanesulfonic Acid (PFOS). Existing feeding guidelines for testing are described in multiple methods but are open to interpretation. The current study sought to determine the impact o...
Geographical variation in Canarium indicum (Burseraceae) nut characteristics across VanuatuNARA Subscribed
Tropical forests in the Pacific region contain many tree species that bear edible nuts (kernels). Canarium indicum (canarium) is an overstorey tree indigenous to Melanesia that produces commercially valuable kernels due to their pleasant taste and high oil content. This study characterises natural variation in fruit, nut-in-shell (NIS) and kernels of C. indicum across eight islands in Vanuatu. Significant tree-to-tree variatio...
The surface ocean is the main source of iodine to the atmosphere, where it plays a crucial role including in the catalytic removal of tropospheric ozone. The availability of surface oceanic iodine is governed by its biogeochemical cycling, the controls of which are poorly constrained. Here we show a near two-year time series of the primary iodine species, iodide, iodate and dissolved organic iodine (DOI) in inner shelf marine...
To date, 23 species of trematodes have been reported in bats from Mexico. However, in some regions of Mexico, such as the Yucatan Peninsula, many species of bats do not have helminthological records. Here, we sampled bats in four localities in Southeastern Mexico from April 2017 to February 2022. Parasites were collected from the intestine of four species of bats: Pteronotus fulvus , Eumops nanus , Noctilio leporinus and Nycti...