Ship lock as a typical hydraulic structure has become an important node in waterway transportation. Due to the long operating life and high demand of throughput, many locks are under the overloaded operation situation. However, the service condition assessment of ship locks has rarely been directly studied, and there is a lack of an efficient and standardized method owing to the complex structure of the ship lock system. In th...

The synthetase 3β-hydroxysterol-Δ24 reductase (DHCR24) is a key regulator involved in cholesterol synthesis and homeostasis. A growing body of evidence indicates that DHCR24 is downregulated in the brain of various models of Alzheimer’s disease (AD), such as astrocytes isolated from AD mice. For the past decades, astrocytic tau pathology has been found in AD patients, while the origin of phosphorylated tau in astrocytes remain...