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Springer Nature1
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GeroScience1
Publication Year
20231
Meredith D. Murrell results 1 · Newest (Page 1/1, per page 25)
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Author: Meredith D. Murrell ×Clear All Filters
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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules usedNARA Subscribed
GeroScience · 2023 · Vol. 46 · Issue 1 · Springer
David E. Harrison; Randy Strong; Peter Reifsnyder; Nadia Rosenthal; Ron Korstanje; Elizabeth Fernandez; Kevin Flurkey; Brett C. Ginsburg; Meredith D. Murrell; Martin A. Javors; Marisa Lopez-Cruzan; James F. Nelson; Bradley J. Willcox; Richard Allsopp; David M. Watumull; David G. Watumull; Gino Cortopassi; James L. Kirkland; Tamar Tchkonia; Young Geun Choi; Matthew J. Yousefzadeh; Paul D. Robbins; James R. Mitchell; Murat Acar; Ethan A. Sarnoski; Michael R. Bene; Adam Salmon; Navasuja Kumar; Richard A. Miller
In genetically heterogeneous (UM-HET3) mice produced by the CByB6F1 × C3D2F1 cross, the Nrf2 activator astaxanthin (Asta) extended the median male lifespan by 12% ( p = 0.003, log-rank test), while meclizine (Mec), an mTORC1 inhibitor, extended the male lifespan by 8% ( p = 0.03). Asta was fed at 1840 ± 520 (9) ppm and Mec at 544 ± 48 (9) ppm, stated as mean ± SE ( n ) of independent diet preparations. Both were started at 12...
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