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Deformable image registration (DIR) has proven to be an invaluable tool to maximize the clinical benefits of multimodality imaging in radiation oncology. In contrast to rigid image registration (RIR), which is employed at all stages of diagnosis and treatment, the uptake of DIR has been constrained by concerns over the potential for unsafe use. The AAPM Task Group 132 (TG132) published a report on the use of image registration...
Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. To address this...
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibitionNARA Subscribed
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic enzyme, methionine-adenosyl transferase 2A (MAT2A), and the protein arginine methyl transferase (PRMT5). This synthetic lethality has paved the way for the rapid deve...
Understanding and managing the response of marine ecosystems to human pressures including climate change requires reliable large-scale and multi-decadal information on the state of key populations. These populations include the pelagic animals that support ecosystem services including carbon export and fisheries. The use of research vessels to collect information using scientific nets and acoustics is being replaced with techn...
Real-World Evidence of the Top 100 Prescribed Drugs in the USA and Their Potential for Drug Interactions with Nirmatrelvir; RitonavirNARA Subscribed
Nirmatrelvir (coadministered with ritonavir as PAXLOVID TM ) reduces the risk of COVID-19-related hospitalizations and all-cause death in individuals with mild-to-moderate COVID-19 at high risk of progression to severe disease. Ritonavir is coadministered as a pharmacokinetic enhancer. However, ritonavir may cause drug-drug interactions (DDIs) due to its interactions with various drug-metabolizing enzymes and transporters, inc...
Marine protected areas (MPAs), particularly large MPAs, are increasing in number and size around the globe in part to facilitate the conservation of marine megafauna under the assumption that large-scale MPAs better align with vagile life histories; however, this alignment is not well established. Using a global tracking dataset from 36 species across five taxa, chosen to reflect the span of home range size in highly mobile ma...
Drivers of ecosystem vulnerability to Corbicula invasions in southeastern North AmericaNARA Subscribed
Invasive species introduction is one of the major ongoing ecological global crises. Identifying factors responsible for the success of invasive species is key for the implementation of effective management actions. The invasive filter-feeding bivalve, Corbicula , is of particular interest because it has become ubiquitous in many river basins across North America and elsewhere. Here we sampled bivalve assemblages, environmental...
Isolation of the Hawaiian archipelago produced a highly endemic and unique avifauna. Avian malaria ( Plasmodium relictum ), an introduced mosquito‐borne pathogen, is a primary cause of extinctions and declines of these endemic honeycreepers. Our research assesses how global climate change will affect future malaria risk and native bird populations. We used an epidemiological model to evaluate future bird–mosquito–malaria dynam...
Sex hormones and skeletal muscle weaknessNARA Subscribed
This study compared the longitudinal size distribution of bluegill bullies ( Gobiomorphus hubbsi ) from Hutt River with existing data on the size distributions of bluegill bullies and torrentfish ( Cheimarrichthys fosteri) from Rakaia River, New Zealand. All populations had longitudinal trajectories that showed some increase in size with distance upstream. This increase in size appeared to primarily reflect the influence of am...
This study tested the ability of bluegill bullies ( Gobiomorphus hubbsi ) to detect and respond to the odour of conspecific fish upstream under neutrally odoured (rainwater) and naturally odoured (stream water) conditions. Bluegill bullies were presented with a choice of two flows of water to move into, one of which contained the odour of conspecific fish. Bluegill bullies displayed a concentration‐dependent reaction under neu...
A leading theory for the cause of the decline of Steller sea lions is nutritional stress, which led to chronic high juvenile mortality and possibly episodic adult mortality. Nutritional stress may have resulted from either poor quality or low abundance of prey. The objective of this study was to determine whether we could predict shifts in body condition ( i.e. , body mass or body fat content) over different seasons associated...