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Although marine sediments are recognized as a sink for marine microplastic particles, investigations into the fate of once deposited particles have received relatively little interest so far. Through interactions with sediment-dwelling organisms, these particles are subject to potential burial in the wake of bioturbation. In this study, we analyzed the effect of sediment reworking by the polychaete Hediste diversicolor O.F. Mü...
Putative Mechanisms for Initial Reaction of Anaerobic Benzene Degradation Presumably Involving a FlavoproteinNARA Subscribed
Biodegradation of benzene is most challenging among the plethora of hydrocarbons due to its high chemical stability. While aerobic bacteria employ O 2 ‐dependent oxygenases to overcome the high energy barrier, anaerobic benzene degradation remains enigmatic. Here we achieve an anaerobic enrichment, which is clonal with respect to the benzene‐degrading, sulphate‐reducing, marine bacterium BzS1, from a previously reported enrich...
Purpose Overcoming the limitations of synthetic vascular grafts in the development of biocompatible and regenerative vessels remains a long-term objective in tissue engineering. In this study, we engineered large-diameter fibrin-based vascular grafts with a target inner diameter of 21 mm replicating all three layers of the native human vessel wall in vitro. Methods The Tunica media was reconstructed using a compressed high-den...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Quantitative assay to analyze neutralization and inhibition of authentic Middle East respiratory syndrome coronavirusNARA Subscribed
To date, there is no licensed vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV). Therefore, MERS-CoV is one of the diseases targeted by the Coalition for Epidemic Preparedness Innovations (CEPI) vaccine development programs and has been classified as a priority disease by the World Health Organization (WHO). An important measure of vaccine immunogenicity and antibody functionality is the detection of virus-ne...
The deubiquitinating enzyme CYLD negatively regulates NF-κB signaling by removing activating ubiquitin chains from several members of the NF-κB pathway. Thereby, CYLD is critical for the maintenance and differentiation of various immune cells. Despite the importance of the NF-κB pathway in microglia regulation, the role of CYLD in microglia has not been investigated so far. In this study, we investigated whether CYLD in microg...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The common dolphin ( Delphinus delphis ) is a widely distributed species exhibiting extensive morphological diversity, with previous taxonomies recognizing multiple Delphinus species primarily based on relative beak length. We sequenced mitochondrial genomes of D. delphis morphotypes from multiple regions, calculated mitogenome nucleotide diversity (π = 0.00504), dated Delphinus mitogenome diversification to 1.27 mya, and cond...