High flow therapy (HFT) delivers heated and humidified gas at flow rates up to 60 L/min to hypoxemic subjects, but is not conducive to simultaneous administration of pharmaceutical aerosols. Aerosol losses occur due to circuit wall impaction, environmental loss and particle growth from high humidity; resulting in poor lung delivery efficiency. This study compares two strategies for delivering dry powder aerosols during 60 L/mi...

Within the bovine immune response, a distinct type of immunoglobulin (Ig), known as ultralong complementarity-determining region 3 (CDR3) antibodies, coexists alongside canonical Igs. These ultralong heavy chains (HC) feature a remarkable structure with a lengthened CDR3 of the heavy chain (CDR H3), allowing them to adopt either a smaller and more extended paratope than canonical antibodies. However, very little is known about...

This study examines the variation and trends in wave parameters across the Arctic, including the marginal ice zone (MIZ), by comparing historical data (1980–2009) with projections for a future climate scenario (2070–2099) as outlined by the IPCC. Utilizing the WAVEWATCH III (WW3) numerical wave prediction model, we simulate the wave climate for these periods, incorporating advanced parameterizations to account for wave-ice int...

Hurricane Epsilon (2020) was a late-season, category-3 tropical cyclone that underwent extratropical transition and became Extratropical Cyclone Epsilon on October 26. The upper ocean response to the passage of the storm was observed by three types of autonomous platforms: an eXpendable Spar buoy, an Air-Launched Autonomous Micro-Observer profiling float, and two Seagliders. Taken together, this array enabled the rare collecti...

Pediatric obesity is a major public health concern. Genetic susceptibility and increased availability of energy-dense food are known risk factors for obesity. However, the extent to which these factors jointly bias behavior and neural circuitry towards increased adiposity in children remains unclear. While undergoing fMRI, 108 children (ages 5-11y) performed a food-specific go/no-go task. Participants were instructed to either...

Understanding how human infrastructure and other landscape attributes affect genetic differentiation in animals is an important step for identifying and maintaining dispersal corridors for these species. We built upon recent advances in the field of landscape genetics by using an individual‐based and multiscale approach to predict landscape‐level genetic connectivity for grizzly bears ( Ursus arctos ) across ~100,000 km 2 in C...

Participatory approaches to science and decision making, including stakeholder engagement, are increasingly common for managing complex socio-ecological challenges in working landscapes. However, critical questions about stakeholder engagement in this space remain. These include normative, political, and ethical questions concerning who participates, who benefits and loses, what good can be accomplished, and for what, whom, an...