Silage maize cultivation in Central Europe offers significant potential for improving nitrogen (N) efficiency, but quantifying N savings under current fertilization regulations and identifying further opportunities for improvement remain crucial. This study addresses these gaps by analyzing the influence of site-specific and management factors on the economically optimal N fertilization rate (EONR). EONR was calculated for 223...

Optimizing nitrogen (N) efficiency in European silage maize cultivation requires better quantification of N savings beyond existing regulations and identifying further opportunities to enhance efficiency. This study focuses on understanding how site and management factors influence net N mineralization. A comprehensive dataset from silage maize field trials across five Central European countries was analyzed using a multistage...

Recent increases in frequency and intensity of warm water anomalies and marine heatwaves have led to shifts in species ranges and assemblages. Genomic tools can be instrumental in detecting such shifts. In the early stages of a project assessing population genetic structure in Pacific Sardine ( Sardinops sagax ), we detected the presence of Japanese Sardine ( Sardinops melanosticta ) along the west coast of North America for t...

Purpose Vericiguat reduced clinical endpoints in patients experiencing worsening heart failure in clinical trials, but its implementation outside trials is unclear. Methods This retrospective analysis of longitudinally collected data was based on the IQVIA™ LRx database, which includes ~ 80% of the prescriptions of the 73 million people covered by the German statutory health insurance. Results Between September 2021 and Decemb...

Citizen science (CS) can foster transformative impact for science, citizen empowerment and socio-political processes. To unleash this impact, a clearer understanding of its current status and challenges for its development is needed. Using quantitative indicators developed in a collaborative stakeholder process, our study provides a comprehensive overview of the current status of CS in Germany, Austria and Switzerland. Our onl...

Cross‐kingdom interactions involve dynamic processes that shape terrestrial ecosystems and represent striking examples of co‐evolution. The multifaceted relationships of entomopathogenic nematodes with their insect hosts and symbiotic bacteria are well‐studied cases of co‐evolution and pathogenicity. In contrast, microbial interactions in soil after the natural death of insects and other invertebrates are minimally understood....

Zusammenfassung Mit einem Multi-Modell-Ensemble wurde analysiert, wie sich der Klimawandel auf den Grundwasserhaushalt in Nordrhein-Westfalen (NRW) auswirkt. Hierzu wurden Projektionen der zukünftigen Grundwasserneubildung für insgesamt 36 Mitglieder der Modellkette RCP-GCM-RCM-mGROWA, bestehend aus 3 RCP-Szenarien zukünftiger globaler Erwärmung, 6 globalen und 5 dynamischen regionalen Klimamodellen sowie dem Wasserhaushaltsmo...

A multiphase-field approach for elasto-plastic and anisotropic brittle crack propagation in geological systems consisting of different regions of brittle and ductile materials is presented and employed to computationally study crack propagation. Plastic deformation in elasto-plastic materials such as frictional, granular or porous materials is modelled with the pressure-sensitive Drucker-Prager plasticity model. This plasticit...

COR-101 is a fully human, Fc silenced IgG that was discovered by antibody phage display. It reduced the SARS-CoV-2 virus load in the lung by more than 99 percent in Hamster models and led to much faster recovery. Its mode of action has been elucidated by solving the atomic structure of its interaction with SARS-CoV-2. The antibody competes with ACE2 binding by blocking a large area of the SARS-CoV-2 spike protein.

Transmembrane BAX inhibitor motif containing 6 (TMBIM6), also known as Bax inhibitor-1, is an evolutionarily conserved protein involved in endoplasmic reticulum (ER) function. TMBIM6 is an ER Ca 2+ leak channel and its deficiency enhances susceptibility to ER stress due to inhibition of the ER stress sensor IRE1α. It was previously shown that TMBIM6 overexpression improves glucose metabolism and that TMBIM6 knockout mice devel...

We developed a generalized multiphase-field modeling framework for addressing the problem of brittle fracture propagation in quartz sandstones at microscopic length scale. Within this numerical approach, the grain boundaries and crack surfaces are modeled as diffuse interfaces. The two novel aspects of the model are the formulations of (I) anisotropic crack resistance in order to account for preferential cleavage planes within...

Tidal wetlands contain large reservoirs of carbon in their soils and can sequester carbon dioxide ( CO 2 ) at a greater rate per unit area than nearly any other ecosystem. The spatial distribution of this carbon influences climate and wetland policy. To assist with international accords such as the Paris Climate Agreement, national‐level assessments such as the United States (U.S.) National Greenhouse Gas Inventory, and region...