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Springer Nature2
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✓BioMetals2
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20261
20251
Michael Howe results 2 · Newest (Page 1/1, per page 25)
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Journal: BioMetals ×Author: Michael Howe ×Clear All Filters
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Autophagy-dependent cell death and immune responses induced by heteroleptic copper(II), manganese(II), and silver(I) complexes containing dicarboxylate and 1,10-phenanthroline ligands: novel insights from in vitro and in vivo modelsNARA Subscribed
BioMetals · 2026 · Vol. 39 · Issue 1 · Springer
Ella O’Sullivan; Denis O’Shea; Michael Devereux; Kevin Kavanagh; Orla Howe
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Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?NARA Subscribed
BioMetals · 2025 · Vol. 38 · Issue 3 · Springer
Ella O’Sullivan; Denis O’Shea; Michael Devereux; Orla Howe
Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screening of the complexes demonstrated all the metal-dicarboxylate-phenanthroline comp...
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