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Surveying the scene: A review of how landscapes are valuedNARA Subscribed
Warming Temperatures to Expand Spruce Beetle Outbreak Distribution in Northern but Not Southern Picea Forests of Western North AmericaNARA Subscribed
Aim The biogeography and distribution of irruptive forest insect herbivores are driven by population level responses to host availability, temperature, and precipitation. Because the irruptive dynamics of tree‐killing insects such as spruce beetle are regulated by climate, it is imperative to quantify biogeographic drivers and limiters to develop informed predictions and forecasts of future outbreaks. Here, we: (1) identify su...
Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screening of the complexes demonstrated all the metal-dicarboxylate-phenanthroline comp...
There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and...
In this pilot project, World Wild Fund for Nature (WWF) Germany works together with regional divers, fisherfolk and public authorities to reduce the impact of lost fishing gear in the Baltic Sea. If not removed, ghost gear poses a threat to the marine environment and wildlife including seabirds, seals, harbour porpoises and fish. Over decades to centuries, lost fishing nets and ropes shed microplastic fibres into the marine en...
Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal ModelNARA Subscribed
The objective of this study was to characterize the effects of multiple nasal prong interface configurations on nasal depositional loss of pharmaceutical aerosols in a preterm infant nose-throat (NT) airway model. Benchmark in vitro experiments were performed in which a spray-dried powder formulation was delivered to a new preterm NT model with a positive-pressure infant air-jet dry powder inhaler using single- and dual-prong...
Vessel strike and entanglement in fishing gear are global threats to large whales. United States management actions to reduce human-induced serious injury and mortality to large whales have been inadequate, partially due to static, spatial protection schemes that fail to adjust to distribution shifts of highly mobile animals. Whale conservation would benefit from dynamic ocean management, but few tools exist to inform dynamic...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging studyNARA Subscribed
Rationale There is growing interest in the therapeutic potential of cannabidiol (CBD) across a range of psychiatric disorders. CBD has been found to reduce anxiety during experimentally induced stress in anxious individuals and healthy controls. However, the mechanisms underlying the putative anxiolytic effects of CBD are unknown. Objectives We sought to investigate the behavioural and neural effects of a single dose of CBD vs...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Climate‐induced outbreaks in high‐elevation pines are driven primarily by immigration of bark beetles from historical hostsNARA Subscribed
Warming temperatures are allowing native insect herbivores to expand into regions that previously exceeded their thermal tolerance, encounter new host species, and pose significant threats to native communities. However, the dynamics of these expansions remain poorly understood, particularly in the extent to which outbreaks remain reliant on emigration from historical hosts or are driven by local reproduction within novel host...
Terrestrial runoff can negatively impact marine ecosystems through stressors including excess nutrients, freshwater, sediments, and contaminants. Severe storms, which are increasing with global climate change, generate massive inputs of runoff over short timescales (hours to days); such runoff impacted offshore reefs in the northwest Gulf of Mexico (NW GoM) following severe storms in 2016 and 2017. Several weeks after coastal...
Search for top‐down and bottom‐up drivers of latitudinal trends in insect herbivory in oak trees in EuropeNARA Subscribed
Aim The strength of species interactions is traditionally expected to increase toward the Equator. However, recent studies have reported opposite or inconsistent latitudinal trends in the bottom‐up (plant quality) and top‐down (natural enemies) forces driving herbivory. In addition, these forces have rarely been studied together thus limiting previous attempts to understand the effect of large‐scale climatic gradients on herbi...