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Recent advances in the detection and functional analysis of circRNAs with short-read RNA sequencing-based methodsNARA Subscribed
Circular RNAs (circRNAs) were first identified approximately 50 years ago in pathogenic viroids as single-stranded, covalently closed RNA molecules. Initially considered by-products of splicing, circRNAs are now recognised as an important class of regulatory RNAs involved in microRNA sponging, RNA–protein interactions, and cellular pathways. Their closed-loop structure, generated through backsplicing, confers resistance to exo...
Utilisation of Machine Learning Approaches Improves RNA-Seq Transcriptome Analyses in Alzheimer’s Disease BrainNARA Subscribed
Alzheimer’s disease (AD) is a neurodegenerative disorder that progressively deteriorates a person’s memory, as well as their ability to think and move. It has been reported to be the most common cause of dementia. Alterations in gene expression have been increasingly recognised as key contributors to the onset and progression of AD, driving interest in transcriptomic approaches to better understand the disease at a molecular l...
Discovery of Novel Protein-Coding and Long Non-coding Transcripts in Distinct Regions of the Human BrainNARA Subscribed
Recent improvements in the accuracy of long-read sequencing (LRS) technologies have expanded the scope for novel transcriptional isoform discovery. Additionally, these advancements have improved the precision of transcript quantification, enabling a more accurate reconstruction of complex splicing patterns and transcriptomes. Thus, this project aims to take advantage of these analytical developments for the discovery and analy...
Circular RNAs (circRNAs) are a subclass of non-coding RNAs which have demonstrated potential as biomarkers for Alzheimer’s disease (AD). In this study, we conducted a comprehensive exploration of the circRNA transcriptome within AD brain tissues. Specifically, we assessed circRNA expression patterns in the dorsolateral prefrontal cortex collected from nine AD-afflicted individuals and eight healthy controls. Utilising two circ...
Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course of disease. Suspicious lymph nodes (LN) in staging imaging are a frequent topic of discussion in multidisciplinary tumor boards. Predictive markers are needed to facilitate stratification and improve treatment of STS patients. In this study, 56 STS patients with radiologically suspicious and subsequently...
Inter-slice leakage and intra-slice aliasing in simultaneous multi-slice echo-planar imagesNARA Subscribed
Simultaneous multi-slice (SMS) imaging is a popular technique for increasing acquisition speed in echo-planar imaging (EPI) fMRI. However, SMS data are prone to motion sensitivity and slice leakage artefacts, which spread signal between simultaneously acquired slices. Relevant to motion sensitivity, artefacts from moving anatomic structures propagate along the phase-encoding (PE) direction. This is particularly relevant for ey...
Body size drives allochthony in food webs of tropical riversNARA Subscribed
Individual filamentous phage imaged by electron holographyNARA Subscribed
Poster abstractsNARA Subscribed
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