Weiss-Kruszka syndrome (WSKA; OMIM 618619) is a rare autosomal dominant neurodevelopmental disorder caused by haploinsufficiency of ZNF462, a zinc-finger transcription factor involved in chromatin regulation and early embryonic development. WSKA is characterized by developmental delay, hypotonia, craniofacial dysmorphic features (around 8) and variable congenital anomalies. Genome-wide DNAm profiling was performed on periphera...

The geomorphic stability of coral reef islands depends on a continued supply of biologically derived sediment from reefs. However, the ecological processes that produce detrital sediment remain poorly resolved. The role of fishes as sediment producers has largely focused on coral sand generated by parrotfishes (Labridae: Scarinae) in clear-water settings, while the contribution of other groups, such as durophagous invertivores...

mRNA localisation is a critical posttranscriptional mechanism that confers a spatiotemporal dimension to the control of gene expression. Among diverse outcomes, this process can result in compartmentalised protein synthesis and consequently, elicit localised cellular responses. Targeting mRNAs to their destination is often determined by localisation elements (LEs) contained in untranslated regions within targeted transcripts....