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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Reconstructing the demographic history of orang‐utans using Approximate B ayesian ComputationNARA Subscribed
Investigating how different evolutionary forces have shaped patterns of DNA variation within and among species requires detailed knowledge of their demographic history. O rang‐utans, whose distribution is currently restricted to the S outh‐ E ast A sian islands of B orneo ( P ongo pygmaeus ) and S umatra ( P ongo abelii ), have likely experienced a complex demographic history, influenced by recurrent changes in climate and sea...
Stable‐isotope probing of the polycyclic aromatic hydrocarbon‐degrading bacterial guild in a contaminated soilNARA Subscribed
Summary The bacteria responsible for the degradation of naphthalene, phenanthrene, pyrene, fluoranthene or benz[ a ]anthracene in a polycyclic aromatic hydrocarbon (PAH)‐contaminated soil were investigated by DNA‐based stable‐isotope probing (SIP). Clone libraries of 16S rRNA genes were generated from the 13 C‐enriched (‘heavy’) DNA recovered from each SIP experiment, and quantitative PCR primers targeting the 16S rRNA gene we...
Summary Uncultivated bacteria associated with the degradation of pyrene in a bioreactor treating soil contaminated with polycyclic aromatic hydrocarbons (PAH) were identified by DNA‐based stable‐isotope probing (SIP) and quantified by real‐time quantitative PCR. Most of the 16S rRNA gene sequences recovered from 13 C‐enriched DNA fractions clustered phylogenetically within three separate groups of β‐ and γ‐Proteobacteria unass...
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