Zusammenfassung Die Studie untersucht die Entwicklung der Grundwasserstände in Deutschland anhand von 5844 Messstellen sowie deren Reaktionsdynamik gegenüber klimatologischen Antrieben im Referenzzeitraum 1991–2020. Zusätzlich wird die Entwicklung seit 2018 im Kontext der außergewöhnlichen Dürreperiode betrachtet, um die Reaktionsfähigkeit und Vulnerabilität der Grundwassersysteme gegenüber extremen klimatischen Bedingungen zu...

Formaldehyde is highly reactive, causing irritation and acute and chronic toxicity in target tissues (the eyes, respiratory tract, and skin) following inhalation and/or skin contact. Moreover, formaldehyde is a local carcinogen after inhalation exposure. It induces nasal squamous cell carcinoma in laboratory animals and nasopharyngeal carcinoma in humans, albeit less convincingly. While formaldehyde has been evaluated and clas...

Wild rodents are important reservoirs and vectors of various pathogens, and play a crucial role in the spread of zoonotic pathogens. The garden dormouse ( Eliomys quercinus ), an arboreal nocturnal rodent species native to Europe, has declined throughout much of its natural range in recent decades. The reason for this ongoing decline is not yet fully understood, but infectious diseases may play a role. This study aimed to revi...

Understanding responses of ecological communities to shocks that displace species abundances is of paramount importance given the increasing frequency of extreme climatic events. However, current theory on responses to such pulse perturbations focuses on equilibrium points and we lack a unified framework that accommodates other common, but more complicated, population fluctuations such as transients and cycles. Here we introdu...

A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological an...

This review discusses important pests and pathogens that could be associated with the cultivation of new crops in Germany, focusing on quinoa, cannabis, and ginger. As Germany diversifies its agricultural landscape, these crops are gaining popularity due to various factors such as nutritional value, medicinal and recreational uses, and culinary enrichment. The paper highlights the potential risks of introducing and spreading n...

Lightweight design is very closely associated with additive manufacturing. Besides the design possibilities offered by this technology, the material used also plays a key role. Especially in the LPBF process, the production of the powder and the processing of the material is a major challenge. This applies in particular to magnesium alloys as a lightweight material. Due to its low density and good strength and rigidity propert...

The Messel Pit is a Konservat-Lagerstätte in Germany, representing the deposits of a latest early to earliest middle Eocene maar lake, and one of the first palaeontological sites to be included on the list of UNESCO World Heritage Sites. One aspect of Messel that makes it so extraordinary is that its sediments are rich in different fossilised organisms – microfossils, plants, fungi, invertebrate animals and vertebrates – that...

Atoguanil™ is a novel complex of atovaquone (ATV) and proguanil (PG) with enhanced ATV bioavailability compared to Malarone®. This pilot study assessed whether the relative bioavailability (F rel ) of ATV, PG, and the primary PG metabolite cycloguanil (CG) following a single oral dose in the fed state of Atoguanil was similar to Malarone despite a 50% lower ATV dose. This open-label, single-dose, randomized 2-period, 2-treatme...

Background and aim Root exudates are the main drivers of plant-microbes-soil interactions. There are several approaches to collect root exudates, but critical methodological evaluation remains limited. The goal of this study was to assess the effect of the applied sampling solution volume and to test the suitability of Micropur as microbial activity inhibitor during the exudate sampling process. Methods Using Zea mays L. as mo...