Introduction Practitioners routinely use intravenous lipid emulsion for local anesthetic systemic toxicity, but its role in non-local anesthetic poisonings remains unclear. We conducted a systematic review and meta-analysis comparing lipid emulsion with standard care for non-local anesthetic toxicities. Methods We searched PubMed, Embase, Scopus and Web of Science from January 1st 2010 until March 16th 2026 for human randomize...

Aim Energy availability is often assumed to be a primary driver of variation in biodiversity across large‐scale environmental gradients such as elevation, but support for the role of energetic constraints is far from universal. Here, we assume that these variations in energy–richness relationships might arise from the degree of match between the scale of the response of organisms to energy (response scale) and the scale of the...

Elevated carbon dioxide (eCO 2 ) acts as a fertiliser for photosynthesis, driving an increase in gross primary production (GPP). However, it is unclear how effectively increased GPP propagates along the ‘carbon (C) cascade’ to increase net primary production (NPP) and vegetation C stocks ( C veg ) in different plant compartments. Vegetation models were criticised for being overly sensitive to photosynthesis (source‐driven), ne...

The hyperiid amphipod Brachyscelus rapacoides is a warm-water species associated with gelatinous zooplankton. In the Mediterranean it has been reported in association with Rhopilema nomadica in both Israel and Turkey. Here, we document the first record of B. rapacoides in Greek waters, representing the first confirmed record for Europe, based on both morphological examination and DNA barcoding of the mitochondrial COI gene. Sp...

Peroxisomes are ubiquitous, oxidative organelles in eukaryotes with conserved functions in cellular lipid metabolism and redox balance. They are now recognised as key metabolic organelles of medical importance, with contributions to antiviral signalling, pathogen defence, innate immunity, cancer and neurodegeneration. Our current knowledge of peroxisomes and the molecular understanding of their diverse functions and roles in d...

Deep learning has transformed image analysis across scientific domains, but its application in geosciences remains limited by scarce training data. Traditional image augmentation techniques, such as translation, rotation, and flipping, fail to capture the complexity and range of subsurface geological feature configurations. Here, we demonstrate that mathematical morphology-based image augmentation significantly improves the pe...

Tissue biodistribution characterization represents a critical component of monoclonal antibody (mAb) development, yet industry practices remain fragmented despite regulatory emphasis on comprehensive exposure assessment. The IQ Consortium Tissue Concentration Working Group surveyed eleven pharmaceutical companies to evaluate current methodologies in mAb tissue concentration analysis and establish consensus recommendations. Org...

Despite the rapid development of nanoparticle (NP)-based drug delivery systems, intravenous delivery of drugs to the brain remains a major challenge due to various biological barriers. To achieve therapeutic effects, NP-encapsulated drugs must avoid accumulation in off-target organs and selectively deliver to the brain, successfully cross the blood–brain barrier (BBB), and reach the target cells in the brain. Conjugating recep...

This study critically examines China's experimentation with Total Allowable Catches (TACs) as a central element of its evolving fisheries management system. Based on policy review, cross‐case analysis of 32 pilot programs, expert surveys, and stakeholder interviews, we trace how political commitment, institutional trials, and stakeholder engagement have shaped TAC implementation since 2017. The pilots showed that TACs can be m...