Understanding how nanoplastics (NPLs) exposure affects vascular endothelium is essential for determining their potential cardiovascular risk. To this end, four different NPLs of similar nominal sizes (about 200 nm), but different environmental relevance, have been used. They are: (i) spherical and monodisperse pristine polystyrene (PS), (ii) biodegradable polylactic acid (PLA), (iii) moderately irregular and polydisperse polyt...