Michiel Simons results 14
· Newest (Page 1/1, per page 25)
Author: Michiel Simons ×Clear All Filters
Search Results
Opportunities to improve detection of genetic predisposition for ovarian cancer applying the Tumor-First workflowNARA Subscribed
Genetic testing in ovarian carcinoma (OC) patients is very important for patients and their relatives. The Tumor-First workflow uses a tumor DNA test to stratify germline testing for hereditary cancer predisposition as well as treatment options with PARP inhibitors. This workflow is adopted and successfully implemented nationwide. Here, we evaluated recent tumor DNA testing rates in the Netherlands to identify untested OC pati...
Evidence for successive breaching events by basking sharks Cetorhinus maximus (Lamniformes: Cetorhinidae)NARA Subscribed
Basking sharks were recorded breaching frequently off the coast of Co Clare, Ireland. The frequency and time between breaching events were analysed to determine any patterns in this behaviour. A total of 93 breaches of basking sharks were recorded over a 3-day period in September 2020. The mean number of breaches per hour, during a total observation period of 515 min, ranged from 6.0 to 15.3 with a mean ± SD of 9.2 ± 4.3 breac...
Environmental and Geographic Conditions on the Breeding Grounds Drive Bergmannian Clines in NightjarsNARA Subscribed
Aim To evaluate (1) whether three migratory nightjar species (Family Caprimulgidae) adhere to Bergmann's rule, (2) whether environmental factors on the breeding or wintering grounds determine body size, and (3) which mechanistic hypotheses best explain Bergmannian patterns in body size. Location North and South America; Europe and Africa. Taxon Eastern whip‐poor‐will ( Antrostomus vociferus ), Common nighthawk ( Chordeiles min...
Non-serous ovarian cancer in PTEN Hamartoma Tumor Syndrome: additional evidence for increased riskNARA Subscribed
Increased hereditary cancer risk is one of the hallmarks of PTEN Hamartoma Tumor Syndrome (PHTS) which is caused by a pathogenic germline variant in PTEN . Case reports and some cohort studies have described ovarian cancer (OC) in PHTS patients. Previously, we observed an enrichment of non-serous OC in PHTS compared to sporadic cases (3% vs 1%). However, ovarian cancer is currently not considered a PHTS-related cancer. The aim...
Farmland biodiversity monitoring through citizen science: A review of existing approaches and future opportunitiesNARA Subscribed
Biodiversity monitoring in agricultural landscapes is important for assessing the effects of both land use change and activities that influence farmland biodiversity. Despite a considerable increase in citizen science approaches to biodiversity monitoring in recent decades, their potential in farmland-specific contexts has not been systematically examined. This paper therefore provides a comprehensive review of existing citize...
Machine learning techniques to characterize functional traits of plankton from image dataNARA Subscribed
Plankton imaging systems supported by automated classification and analysis have improved ecologists' ability to observe aquatic ecosystems. Today, we are on the cusp of reliably tracking plankton populations with a suite of lab‐based and in situ tools, collecting imaging data at unprecedentedly fine spatial and temporal scales. But these data have potential well beyond examining the abundances of different taxa; the individua...
EurOP2E – the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachersNARA Subscribed
Purpose Sharing and developing digital educational resources and open educational resources has been proposed as a way to harmonize and improve clinical pharmacology and therapeutics (CPT) education in European medical schools. Previous research, however, has shown that there are barriers to the adoption and implementation of open educational resources. The aim of this study was to determine perceived opportunities and barrier...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Species richness declines and biotic homogenisation have slowed down for NW ‐European pollinators and plantsNARA Subscribed
Concern about biodiversity loss has led to increased public investment in conservation. Whereas there is a widespread perception that such initiatives have been unsuccessful, there are few quantitative tests of this perception. Here, we evaluate whether rates of biodiversity change have altered in recent decades in three European countries (Great Britain, Netherlands and Belgium) for plants and flower visiting insects. We comp...
Previous1Next