Cytotoxic edema (CE) is a radiographic marker of early tissue injury in cerebral venous thrombosis (CVT) associated with poor outcomes, yet its mechanistic pathway remains unclear. We investigated whether intraparenchymal hemorrhage (IPH) mediates the association between CE and outcomes. We conducted a retrospective cohort study using the multicenter CLOT-VENUS registry, including acute CVT patients treated at two Comprehensiv...

Main conclusion Virus-like particles (VLP) from hepatitis C virus were successfully produced in Nicotiana benthamiana plants for the first time, by co-expressing three viral proteins (Core, E1 and E2) in a polycistron-like arrangement. Abstract Hepatitis C virus (HCV) remains a global health challenge, underscoring the need for a preventive vaccine. Virus-like particles (VLP) offer a safe alternative, as they resemble native v...

Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...

The Tzirate Range (TR; 1.5–0.93 Ma) is a volcanic vent cluster within the Michoacán-Guanajuato Volcanic Field (2.5 Ma–present), composed of effusive andesitic to rhyolitic rocks that reflect complex, multi-stage magmatic evolution. By integrating geochemical, mineralogical, isotopic, and morpho-structural data, this study reveals that magma differentiation in the TR was driven by fractional crystallization, magma mixing, and a...

Spinocerebellar ataxia type 10 (SCA10) is a rare, inherited neurological disease caused by an expansion of the non-coding ATTCT pentanucleotide repeat in the ATAXIN 10 gene. It is characterized by cerebellar ataxia and epilepsy. Previous research has demonstrated extensive white and gray matter degeneration, particularly in the cerebellum. However, the impact of the SCA10 mutation on functional connectivity (FC) remains unexpl...