This study evaluated early weaning (EW) versus conventional weaning (CW) and dam parity (DP) effects on carcass traits, meat quality, and the muscle metabolome of male offspring exposed in utero during the intervention. A randomized complete-block design with a 2 × 2 factorial arrangement compared weaning strategies (WS: EW at 150 d lactation/80 d gestation vs. CW at 240 d lactation/170 d gestation) and dam parities (DP: multi...

We document the first records of reef fishes typically associated with mesophotic environments on shallow ( Rhomboplites aurorubens and the pygmy angelfish Centropyge aurantonotus , usually restricted to deeper (>40 m) shelf habitats along the Brazilian coast, were recorded inside Baía de Todos os Santos (BTS). Integrating long‐term ecological and oceanographic monitoring, fisheries information and underwater visual records, w...

Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...

Purpose The European Medicines Agency (EMA) guideline Declaration of Storage Conditions in the Product Information of Medicinal Products (CPMP/QWP/609/96/Rev.2) was last revised in 2007. Since then, advances in stability science, increased climatic variability, and evolving regulatory expectations have highlighted limitations in the framework, particularly the use of vague descriptors such as “room temperature” or “no special...

Background Methotrexate (MTX) remains a cornerstone therapy in autoimmune diseases and oncology; however, substantial interindividual variability in efficacy and toxicity persists. While variability in MTX pharmacokinetics (PK) and pharmacodynamics (PD) has been linked to transporters, folate-cycle enzymes, and intracellular polyglutamate accumulation, the contribution of long non-coding RNAs (lncRNAs) as regulatory modifiers...

Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...

Burial patterns of ancient communities based on the analysis of human remains are difficult to define. In this regard, the existence of a sex bias in megalithic tombs of western Europe remains unclear. Sex estimation using standard osteological methodologies based on dimorphic features is a complex task in commingled and fragmentary human skeletal assemblages, as those found in megalithic burials usually are. Fortunately, adva...

Space is one of the main drivers of biodiversity, as it regulates the underlying processes affecting the distribution and dynamics of species and communities. It is a fundamental factor when considering the rapid climate and land cover changes occurring at local and global scales, which are linked to habitat loss and fragmentation, as well as their impacts on biodiversity. The Atlantic Forest of South America is among the worl...