Autism spectrum disorder (ASD), a neurodevelopmental disorder, is characterized by synaptic dysregulation as its underlying pathophysiological mechanism. AMP-activated protein kinase (AMPK), an intracellular energy sensor, plays a pivotal role in regulating synaptic integrity and function. Current treatments for ASD exhibit limited benefits in alleviating the core symptoms of ASD. Consequently, we investigated the therapeutic...

Allopatric speciation is a widely accepted hypothesis for species distributed across geographic barriers. Meanwhile, niche conservatism, the tendency of species to retain their ancestral ecological traits, helps reinforce genetic differentiation by stabilising species distributions over time and reducing the role of competition in shaping range boundaries. In contrast, hybridisation can occur at the edges of distribution after...