Extracellular ATP is a potent signaling molecule released from various cells throughout the body and is intimately involved in the pathophysiological functions of the nervous system and immune system by activating P2 purinergic receptors. Recent increasingly studies showed that extracellular ATP exhibits circadian oscillation with an approximately 24-h periodicity, which participates in regulatory pathways of central oscillato...

Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. To investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma, we constructed RIG-I knockout, RIG-I -overexpressing B16-F10...

Although explosive cyclones (ECs) have long been a focus of research, there remains a lack of knowledge of the statistical characteristics of their associated maximum surface winds and vertical extents. This study fills this gap by conducting a targeted statistical analysis of ECs in the Northern Hemisphere using the ERA‐I reanalysis data during a 40‐year period. Some new findings are obtained: (a) The average location of form...