The U.S. Food and Drug Administration (FDA) emphasizes drug product development by Quality by Design (QbD). Critical material attributes (CMAs) are a QbD element that has an impact on pharmaceutical operations and product quality. Pharmaceutical drugs often crystallize as needle-shaped (a CMA) particles and affect the process due to poor flowability, low bulk density, and high compressibility, and eventually the product perfor...

Impact of storm surge largely varies depending on the tidal phase during the landfall of a tropical cyclone. This study investigates comparative variance in inundation condition and thrust force for an identical cyclone during low tide and high tide by applying a numerical model (Delft3D) and a semi-analytical model (DFM). A moderate strength cyclone, Mora, which made landfall on Bangladesh coast in May 2017 is selected to stu...