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NARA Subscribed1
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Springer Nature1
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Naunyn-Schmiedeberg's Archives of Pharmacology1
Publication Year
20241
Moritz Trieb results 1 · Newest (Page 1/1, per page 25)
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Author: Moritz Trieb ×Clear All Filters
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Organ-specific off-target effects of Pim/ZIP kinase inhibitors suggest lack of contractile Pim kinase activity in prostate, bladder, and vascular smooth muscleNARA Subscribed
Naunyn-Schmiedeberg's Archives of Pharmacology · 2024 · Vol. 397 · Issue 2 · Springer
Sheng Hu; Moritz Trieb; Ru Huang; Alexander Tamalunas; Patrick Keller; Melanie Götz; Raphaela Waidelich; Christian G. Stief; Martin Hennenberg
Smooth muscle contraction by Pim kinases and ZIPK has been suggested, but evidence for lower urinary tract organs or using Pim-selective inhibitor concentrations is not yet available. Here, we assessed effects of the Pim inhibitors AZD1208 and TCS PIM-1 and the dual ZIPK/Pim inhibitor HS38 on contractions of human prostate and bladder tissues and of porcine interlobar arteries. Human tissues were obtained from radical prostate...
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