Neuropeptide Y (NPY) has emerged as a key modulator of stress resilience, primarily through activation of the Y1 receptor (Y1R). We previously demonstrated that intranasal delivery of the Y1R-selective analog D[His 26 ]NPY at the time of trauma induced by Single Prolonged Stress (SPS), a validated rodent model for post-traumatic stress disorder (PTSD), effectively prevented stress-induced behavioral impairments in male rats. D...