Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon ( 2 ), and 5- epi -7α-hydroxy-( +)-oplopanone ( 3 ), were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five sesquiterpenes; 11-hydroxy-8-oxo-β-cyperon ( 1 ), alismoxide ( 4 ), 5β,8β-epidioxy-11-hydroxy-6-eudesmene ( 5 ), chabrolidione B ( 6 ), 7-oxo-tri-nor-eudesm-5-en-4β-ol ( 7 ), two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)...

Background Psoriasis is a chronic inflammatory immune-mediated and hyper proliferative skin disorder that has underlying genetic factors. Psoriasis can result from interaction of cytokines between keratinocytes and T-lymphocytes. NEAT is a lncRNA involved in immune modulation and has been previously studied in cancers. This study aims to clarify the unprecedented role of NEAT in psoriasis pathogenesis. Methods The study was co...

This study aimed to investigate the effectiveness of curcumin (CCM) against gentamicin (GEN) and sodium salicylates (NaS)-induced ototoxic effects in rats. For 15 consecutive days, seven rat groups were given 1 mL/rat physiological saline orally, 1 mL/rat olive oil orally, 50 mg/kg bwt CCM orally, 120 mg/kg bwt GEN intraperitoneally, 300 mg/kg bwt NaS intraperitoneally, CCM+GEN, or CCM+NaS. The distortion product otoacoustic e...