Quinazolinone derivatives possess a privileged scaffold with variable pharmacological activities. This study conducted an in vitro evaluation of the pyrazine-linked quinazolinone sulfonamide derivative ( PQS ) to assess its anticancer activity, following confirmation of its safety in a normal cell line. Results revealed that PQS has a noteworthy cytotoxic effect on HepG-2 and HeLa cells, indicating its potential anticancer act...

The modulation of gut microbiota presents promising therapeutic possibilities for various health conditions, ranging from gastrointestinal infections to neurodegenerative and mental health disorders. Among the available interventions, gut microbiota modulators (GMMs) such as probiotics and prebiotics have demonstrated significant potential in infection prevention and neuroprotection. Despite these encouraging findings, the cli...

Neurodegenerative disorders present significant challenges to modern medicine because of their complex etiology, pathogenesis, and progressive nature, which complicate practical treatment approaches. Mitochondrial dysfunction is an important contributor to the pathophysiology of various neurodegenerative illnesses, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). This revie...

In this study, a series of novel oxadiazole-based fluorescent dyes were synthesized and thoroughly characterized through spectroscopic analysis, theoretical modeling, and application testing. The structural design incorporated donor–acceptor motifs to promote intramolecular charge transfer (ICT), resulting in strong fluorescence across the violet-to-green spectral region (363–536 nm) with large Stokes shifts. The photophysical...

Piercing-sucking pests infest many strategic crops worldwide, causing significant damage to crops. Botanical natural products provide several promising pesticide agents that could control these pests as an alternative to the negatively impacted synthetic insecticides. Bioassay-guided separation of the alkaloid fraction of Quassia amara Linn. woody parts against two serious pests ( Aphis craccivora Koch and Tetranychus urticae...