Background Muscular dystrophies are a group of inherited neuromuscular disorders characterized by degenerative and progressive muscle weakness. Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and merosin-deficient congenital muscular dystrophy type 1 (MDC1A) are frequent forms caused by DMD (NM_004006.3) and LAMA2 (NM_000426.4) mutations, respectively. Methods and results Our study used whole exome sequencin...

Drought poses a significant threat to agriculture in the transboundary Indus River Basin (IRB), which supports over 300 million people through direct and indirect dependence on agriculture. With limited cropland and growing climatic stress, the basin faces an increasing risk to food security. Yet, comprehensive assessments of cropland exposure to drought under a changing climate and socioeconomic conditions remain lacking. Thi...