Protein tyrosine phosphatase 1B (PTP1B) is a well-known and promising drug target involved in the negative regulation of insulin and leptin signaling, and new anti-diabetic molecules for the treatment of type 2 diabetes are directly in its hands. A series of PTP1B inhibitors was discovered and characterized using in silico techniques, including virtual screening, molecular docking, ADMET profiling, toxicity prediction, VEGA-QS...

Mangoes ( Mangifera indica L.) are notably susceptible to chilling injury (CI) when stored below 13 °C. This temperature threshold is too high for extended storage. Therefore, the influence of postharvest immersion in melatonin (MT) (50, 75, 100 µmol L − 1 ) for 120 min on CI in ‘Kensington Pride’ mangoes kept at 5 ± 1 °C for 21 or 28 d was investigated. The most effective MT concentration was 75 µmol L − 1 causing 36.3% reduc...