Frailty increases the risk of adverse outcomes in older adults and is an important target for preventive care. Clinical frailty measures are established but rarely available at scale due to limited functional data in routine healthcare records. Claims-based frailty prediction models offer a pragmatic approach for population-level risk stratification but are often developed in specific healthcare systems and lack external valid...

Aging is a universal biological process that impacts all tissues, leading to functional decline and increased susceptibility to age-related diseases, particularly cardiometabolic disorders. While aging is characterized by hallmarks such as mitochondrial dysfunction, chronic inflammation, and dysregulated metabolism, the molecular mechanisms driving these processes remain incompletely understood, particularly in a tissue-specif...