Phycobilisomes (PBS), the primary light-harvesting complexes in cyanobacteria, are degraded under nitrogen starvation to provide nitrogen for cell growth. This study reveals that carbon supply is a critical prerequisite for PBS degradation under nitrogen deficiency in Synechococcus sp. PCC 7002. Even under nitrogen-deficient conditions, PBS degradation is inhibited in the absence of sufficient carbon. We demonstrate that both...

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as OX40, plays a crucial role in the regulation of T-cell immune responses under normal physiological conditions. Abnormal expression of OX40 and its cognate ligand OX40L (TNFSF4) have been associated with various autoimmune diseases, indicating that blocking the OX40/OX40L pathway could be a promising strategy for the treatment of a broad range of T cel...

Non-alcoholic steatohepatitis (NASH) is a primary cause of cirrhosis and hepatocellular carcinoma. Unfortunately, there is no approved drug treatment for NASH. AMP-activated kinase (AMPK) is an important metabolic sensor and whole-body regulator. It has been proposed that AMPK activators could be used for treating metabolic diseases such as obesity, type 2 diabetes and NASH. In this study, we screened a marine natural compound...