Access to safe drinking water is a growing global challenge, with billions of people exposed to water scarcity and contamination risks. Heavy metals in drinking water are of particular concern due to their toxic effects on human health and ecosystems. This study assessed the drinking water quality of Hunza Valley, Gilgit-Baltistan, Pakistan, where no comprehensive geospatial evaluation had previously been conducted. A total of...

Background Cefotaxime (CFT) is a broad spectrum, third-generation cephalosporin antibiotic prescribed for the treatment of severe infections, yet dosing guidelines for pediatric with renal impairment is scarce. The current study aimed to develop a physiological based pharmacokinetic (PBPK) model to characterize CFT disposition and model-based recommend dose adjustments in pediatrics with renal impairment. Methods Initially, th...

Rapid urbanization and the intensifying pressures of climate change have elevated solid waste management (SWM) as a critical public service challenge. Evidence on the joint mediating effects of digital transformation and environmental governance between municipal SWM and climate sustainability remains questionable. This study examines the role of SWM in promoting climate sustainability by evaluating environmental management pr...