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Archives of Toxicology · 2026 · Vol. 100 · Issue 8 · Springer
Cardiotoxicity remains the leading driver of drug attrition; however, its prediction remains suboptimal when conventional hERG assays and animal models are used. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a human-relevant alternative that aligns with the CiPA initiative and ICH E14/S7B guidelines. This study validated an integrated platform that combines high-purity hiPSC-CMs with Artificial I...
American Journal of Potato Research · 2026 · Vol. 103 · Issue 4 · Springer
Understanding genotype-by-environment interaction (G×E) is essential for breeding potato cultivars adapted to different regions. We analyzed ~ 13,000 tetraploid breeding lines evaluated over 17 years in Denmark (DK), Spain (ES), and Morocco (MO), representing Scandinavian and Mediterranean mega-environments. A pedigree-based mixed model was fitted for yield, tuber size, and resistance towards scab. Significant G×E was detected...