This paper reports a natural concurrent infection by water moulds of the genera Achlya and Protoachlya in a red tilapia hatchery in Malaysia. In December 2024, a mass mortality of cultured juvenile red tilapia was noticed at 7 days after transportation and introduction into a hatchery. The affected fish showed lethargy at the bottom of the tanks, loss of appetite, pale colouration, and were isolated from the schooling group. F...

Long-term coastal monitoring networks provide the opportunity to evaluate how water-quality predictability varies across contrasting coastal bays. However, most machine learning studies focused on individual stations, optically active variables or short validation periods. We analyze 37 years (1986-2023) of monthly in-situ data from 94 stations across four Hong Kong Bay systems Central Harbours, Eastern Bays, Southern Bays, an...

The purpose of the study is to evalute the in vivo anti -inflammatory activity of newly synthesized cyanoacetate derivatives of succinimides (C-23, C-31, and C-44) and to elucidate their possible mechanisms of action through key inflammatory mediator pathways. Anti-inflammatory activity was assessed using carrageenan-induced paw oedema and arachidonic acid-induced ear oedema models in vivo. Mechanistic involvement was investig...

Protein tyrosine phosphatase 1B (PTP1B) is a well-known and promising drug target involved in the negative regulation of insulin and leptin signaling, and new anti-diabetic molecules for the treatment of type 2 diabetes are directly in its hands. A series of PTP1B inhibitors was discovered and characterized using in silico techniques, including virtual screening, molecular docking, ADMET profiling, toxicity prediction, VEGA-QS...