Purpose The voltage-gated potassium channel K V 1.3 is upregulated on pro-inflammatory microglia, and its blockade is effective in reducing neuroinflammation in vitro and in vivo. The most potent and selective K V 1.3 blockers identified to date are disulfide-rich, venom-derived peptides, which are largely excluded from the brain by the blood–brain barrier (BBB). As BBB shuttle peptides have been reported to promote receptor-m...