Purpose Breast cancer is a significant global health issue, with resistance to doxorubicin (DOX) posing a major challenge to effective treatment. SUMOylation, a post-translational modification process, is linked to cancer progression and therapy resistance. PIAS4, a SUMO E3 ligase involved in maintaining genome stability and stress response, may play a role in these mechanisms. However, its function in breast cancer progressio...

The purpose of the study is to evalute the in vivo anti -inflammatory activity of newly synthesized cyanoacetate derivatives of succinimides (C-23, C-31, and C-44) and to elucidate their possible mechanisms of action through key inflammatory mediator pathways. Anti-inflammatory activity was assessed using carrageenan-induced paw oedema and arachidonic acid-induced ear oedema models in vivo. Mechanistic involvement was investig...

Epitheliocystis is a distinctive and relatively understudied bacterial infection of finfish skin and gill epithelia that occurs intracellularly and results in the enlargement of the host cells. The Candidatus Syngnamydia salmonis is a bacterial pathogen that affects fish, especially salmon species like trout and salmon. The production of Epitheliocystis by Candidatus Syngnamydia salmonis poses several challenges to the aquacul...