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European Journal of Clinical Pharmacology · 2026 · Vol. 82 · Issue 8 · Springer
Background Cefotaxime (CFT) is a broad spectrum, third-generation cephalosporin antibiotic prescribed for the treatment of severe infections, yet dosing guidelines for pediatric with renal impairment is scarce. The current study aimed to develop a physiological based pharmacokinetic (PBPK) model to characterize CFT disposition and model-based recommend dose adjustments in pediatrics with renal impairment. Methods Initially, th...