Epilepsy is a worldwide health issue associated with cardiac-related conditions and Sudden Unexpected Death in Epilepsy (SUDEP). The pathophysiology of SUDEP involves structural fibrosis of the myocardium, a calcium imbalance, and dysfunction of the autonomic nervous system. The objective of this investigation was to examine cardiac damage resulting from epilepsy triggered by the Pentylenetetrazol (PTZ) kindling rat model at a...

Tramadol (TRM) is a commonly prescribed opioid analgesic; however, accumulating evidence suggests that it may exert toxic effects on vital organs, including the lungs. This study aimed to elucidate the mechanisms underlying TRM-induced lung injury and to investigate the potential protective role of rutin (RUT), a bioactive flavonoid with potent antioxidant and anti-inflammatory properties. In a rat model, lung tissues were ana...

Ciprofloxacin (CIP) is a widely used antibiotic frequently associated with dose-limiting nephrotoxicity. Chrysin (CHR), a natural flavonoid, possesses significant cytoprotective properties, yet its specific role in mitigating CIP-induced kidney injury remains underexplored. This study investigates the comprehensive nephroprotective mechanisms of CHR against CIP toxicity in rats. Male Wistar rats received CIP (100 mg/kg/day, i....

The Kahramanmaraş earthquakes on February 6, 2023, with magnitudes of 7.7 and 7.6, are considered the century's worst disaster in Türkiye. It was shown by these two main shocks that the East Anatolian Fault Zone not only often causes destructive earthquakes but also has a focus depth that is only about 10 km deep in the upper crust. The strength of the upper crust plays a crucial role in influencing the structures and fault zo...

Developmental anomalies of the hearing organ, the cochlea, are diagnosed in approximately one-fourth of individuals with congenital. The majority of patients with cochlear malformations remain etiologically undiagnosed due to insufficient knowledge about underlying genes or the inability to make conclusive interpretations of identified genetic variants. We used exome sequencing for the genetic evaluation of hearing loss associ...

Sunshine duration (SD) is one of the critical meteorological parameters used in different fields of application such as climate, renewable energy and agriculture. In this respect, determination and/or estimation of the temporal and spatial variability of SD is critical. Meteorological satellite data/products can be used for estimating SD and in constructing their maps due to their frequent observation of large areas at once. I...