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The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance training intervention in a randomized controlled design to address this knowledge gap. Thirty-nine healthy, untrained males (age ~23 y, sustained contraction group...
Small pelagic fish (SPF) are critical to the trophodynamic structure and function of marine systems and support some of the most valuable and socially important fisheries worldwide. Their “boom and bust” population dynamics, shifts in distribution, and importance as forage resources for other fish stocks place unique challenges to assessing and managing SPF. In response to these challenges, an international working group was f...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Chronic Intermittent Hypoxia Exposure Induces a Unique Microglial Transcriptome in 5XFAD MiceNARA Subscribed
Clinical observations suggest that obstructive sleep apnea (OSA) and Alzheimer’s disease (AD) pathology may be linked; however, causal mechanisms and relationships are unclear. To investigate the potential interaction between amyloidosis and intermittent hypoxia (IH), a hallmark of OSA, starting at 4 months of age 5XFAD mice were exposed to chronic IH (CIH) consisting of 20 episodes per hour of hypoxia for 12 h/day, daily for...
Reticulospinal and corticospinal responses in long-term strength-trained and untrained adultsNARA Subscribed
Purpose Studies investigating neural adaptation to strength training have yet to determine the loci of previously observed improvements in motor pathway function. While transcranial magnetic stimulation (TMS) studies have typically focused on the corticospinal tract, recent evidence from primates suggests that the subcortical reticulospinal tract may be the primary candidate for adaptation. Methods: Using a cross-sectional com...
Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic strokeNARA Subscribed
Background After stroke, recovery of upper limb reaching movements may partly depend on the level of activation of the reticulospinal tract (RST), but few clinical studies have explored this. Here we examined the association between the strength of reticulospinal connections and extent of reaching in post-stroke patients. Methods Fifteen patients (all male) with right hemiparesis who had suffered a stroke at least six months p...
There are many publications over the past 20 years comparing nano-nutrients with their traditional forms. Differently, this study examined the effect of applying nano-Fe and nano-Zn—in two different ways (foliar and soil application)—on sugarcane development, yield, and mineral status using a greenhouse experiment at the National Research Centre. The study results of first yield (plant cane crop) showed that nano-Fe caused an...
Downregulation of Fidgetin-Like 2 Increases Microglial Function: The Relationship Between Microtubules, Morphology, and ActivityNARA Subscribed
The microtubule cytoskeleton regulates microglial morphology, motility, and effector functions. The microtubule-severing enzyme, fidgetin-like 2 (FL2), negatively regulates cell motility and nerve regeneration, making it a promising therapeutic target for central nervous system injury. Microglia perform important functions in response to inflammation and injury, but how FL2 affects microglia is unclear. In this study, we inves...