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Diet-dependent, beneficial and adverse effects of rapamycin on life span of Drosophila melanogasterNARA Subscribed
Rapamycin supplementation has been reported to extend life spans in numerous species, including Drosophila melanogaster , but a recent study in this laboratory revealed a marked life-shortening effect in y w male flies. The experiments reported here were performed to characterize conditions under which rapamycin could extend or shorten life spans in five fly strains. On a cornmeal/torula yeast-based medium, rapamycin extended...
Length‐Based Spawning Potential Ratio Assessment of Key Species From a Remote Recreational Fishery at Diego Garcia, Indian OceanNARA Subscribed
Recreational fisheries in remote regions often operate under limited regulation and data availability, presenting challenges for sustainable management. Diego Garcia, located within the Chagos Marine Protected Area, hosts a unique recreational reef fishery embedded within a highly protected environment. We assessed the stock status of five key species— Lutjanus bohar , L. gibbus , L. monostigma , Caranx melampygus , and Variol...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Digging deeper into cancer resistance in the extraordinarily long-lived naked mole-ratNARA Subscribed
The naked mole-rat (Bathyergidae; Heterocephalus glaber ) is an extremophilic rodent that lives an extraordinarily long and healthy life despite having evolved in harsh, arid, underground conditions. This ~ 31-million-year evolutionary path and concomitant adaptations have surprisingly yielded a broad suite of cytoprotective mechanisms that have enabled them to avoid cancer. Compared to above-ground dwelling species, the incid...