mRNA vaccine formulations are generally considered to pose a lower genotoxic risk than conventional small-molecule pharmaceuticals; however, long-term data regarding their potential genotoxicity remain limited. Furthermore, to date, no standardized genotoxicity testing guidelines specifically tailored to the unique characteristics of mRNA vaccines have been formally established. In this study, we conducted a comprehensive geno...

Respiratory diseases pose a major global public health challenge. With climate change contributing to more frequent and intense heat events, understanding the effects of high temperatures on respiratory health is increasingly critical. However, existing evidence remains inconsistent. A nationwide time-series study was conducted to evaluate the association between daily maximum temperatures and emergency department (ED) visits...

The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effects of SARS-CoV-2 mRNA vaccine candidates formulated with four different types of lipid nanoparticles in ICR mice, focusing on repeated doses and administration routes. We conducted an extensi...

Observation of current speeds in coastal seas is crucial because it can provide useful information for ship operations, fishing activities, and rapid responses to marine disasters. Coastal acoustic tomography (CAT) is a technology that can continuously monitor environmental changes such as current velocity and water temperature using reciprocal acoustic signals between CAT stations in coastal seas. This technology is different...