The CRISPR/Cas genome editing technology, with its advantages of simplicity, high efficiency, and cost‐effectiveness, has become a key tool for dissecting gene function, knocking out harmful/undesirable genes, and repairing defective genes. It has also shown great potential in the genome editing of aquatic animals such as tilapia, carp, salmon, and sea urchins. Disease prevention and control are core areas of aquatic animal re...