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Nanoparticle-induced modulation of indole alkaloid biosynthesis and gene expression in Catharanthus roseus in vitro culturesNARA Subscribed
Catharanthus roseus (L.) G. Don is a key medicinal plant producing pharmacologically important terpenoid indole alkaloids (TIAs). This study aimed to enhance the biosynthesis of three major TIAs; catharanthine (CAT), vincristine (VCR), and vinblastine (VBL) through a stepwise in vitro approach involving callus culture, hairy roots (HRs) induction via Agrobacterium rhizogenes , and elicitation with zinc oxide (ZnO) and chitosan...
Rationale Evidence of the effects of chronic caffeine (CAFF)-containing beverages, alone or in combination with agomelatine (AGO) or quetiapine (QUET), on electroencephalography (EEG), which is relevant to cognition, epileptogenesis, and ovarian function, remains lacking. Estrogenic, adenosinergic, and melatonergic signaling is possibly linked to the dynamics of these substances. Objectives The brain and ovarian effects of CAF...
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