Nicholas Cheng results 46
· Newest (Page 1/2, per page 25)
Author: Nicholas Cheng ×Clear All Filters
Search Results
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Under the current global biodiversity crisis, there is a need for automated and noninvasive monitoring techniques that can gather large amounts of data cost‐effectively at various ecological scales, from local to large spatial scales. These data can then be analyzed to inform stakeholders and decision‐makers. One such technique is passive acoustic monitoring, which is commonly coupled with automatic identification of animal sp...
Introduction Topical brepocitinib, a tyrosine kinase (TYK)2/Janus kinase (JAK)1 inhibitor, is in development for psoriasis (PsO) and atopic dermatitis (AD). Quantitative analyses of prior clinical trial data were used to inform future clinical trial designs. Methods Two phase 2b studies in patients with AD and PsO were used to characterize the amount of topical brepocitinib and the resultant systemic trough concentration ( C T...
Metrics and Considerations for Evaluating How Forest Treatments Alter Wildfire Behavior and EffectsNARA Subscribed
The influence of forest treatments on wildfire effects is challenging to interpret. This is, in part, because the impact forest treatments have on wildfire can be slight and variable across many factors. Effectiveness of a treatment also depends on the metric considered. We present and define human–fire interaction, fire behavior, and ecological metrics of forest treatment effects on wildfire and discuss important consideratio...
Open habitats increase vulnerability of amphibian tadpoles to climate warming across latitudeNARA Subscribed
Aim Global warming and deforestation are pushing species closer to their physiological limit, especially for species with habitat‐restricted life stages because sunlit areas have higher maximum temperatures. Here, we examined the critical thermal maximum (CT max ), and maximum environmental water temperature (T max ) of larvae from 29 anuran species across a latitudinal gradient (22–43° N) to test how latitude and habitat type...
Two heads are better than one: current landscape of integrating QSP and machine learningNARA Subscribed
Quantitative systems pharmacology (QSP) modeling is applied to address essential questions in drug development, such as the mechanism of action of a therapeutic agent and the progression of disease. Meanwhile, machine learning (ML) approaches also contribute to answering these questions via the analysis of multi-layer ‘omics’ data such as gene expression, proteomics, metabolomics, and high-throughput imaging. Furthermore, ML a...
Terrestrial ecosystems regulate Earth's climate through water, energy, and biogeochemical transformations. Despite a key role in regulating the Earth system, terrestrial ecology has historically been underrepresented in the Earth system models (ESMs) that are used to understand and project global environmental change. Ecology and Earth system modeling must be integrated for scientists to fully comprehend the role of ecological...