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Assessment of the accuracy of digital surgical planning and its implementation with tibial plateau levelling osteotomyNARA Subscribed
Introduction Pre-operative planning of orthopaedic procedures is widely regarded as critical to their safe execution; however, the ability to both accurately plan and enact the plan have not been assessed in the veterinary context. The aim of this study was to assess the ability of boarded surgeons compared to surgical trainees to reproducibly plan a TPLO and then to implement this plan in vivo and in vitro . Methods Twelve pa...
Pharmacokinetics and Pharmacodynamics of Nomlabofusp in Non-clinical Studies of Friedreich’s AtaxiaNARA Subscribed
Nomlabofusp is a cell penetrant peptide-based recombinant fusion protein designed to enter cells and deliver human frataxin into the mitochondria of adults and children with Friedreich’s ataxia. In this article we present non-clinical studies evaluating the pharmacology of nomlabofusp, including in a murine striated muscle tissue frataxin knockout model of Friedreich’s ataxia. We demonstrate that subcutaneous administration of...
The relative importance of COVID‐19 pandemic impacts on biodiversity conservation globallyNARA Subscribed
The COVID‐19 pandemic has had an enormous impact on almost all aspects of human society and endeavor; the natural world and its conservation have not been spared. Through a process of expert consultation, we identified and categorized, into 19 themes and 70 subthemes, the ways in which biodiversity and its conservation have been or could be affected by the pandemic globally. Nearly 60% of the effects have been broadly negative...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Paternally‐biased gene expression follows kin‐selected predictions in female honey bee embryosNARA Subscribed
The Kinship Theory of Genomic Imprinting (KTGI) posits that, in species where females mate with multiple males, there is selection for a male to enhance the reproductive success of his offspring at the expense of other males and his mating partner. Reciprocal crosses between honey bee subspecies show parent‐of‐origin effects for reproductive traits, suggesting that males modify the expression of genes related to female functio...
Synchronous biological feedbacks in parrotfishes associated with pantropical coral bleachingNARA Subscribed
Biological feedbacks generated through patterns of disturbance are vital for sustaining ecosystem states. Recent ocean warming and thermal anomalies have caused pantropical episodes of coral bleaching, which has led to widespread coral mortality and a range of subsequent effects on coral reef communities. Although the response of many reef‐associated fishes to major disturbance events on coral reefs is negative (e.g., reduced...
Opsins have evolved under the permanent heterozygote model: insights from phylotranscriptomics of OdonataNARA Subscribed
Gene duplication plays a central role in adaptation to novel environments by providing new genetic material for functional divergence and evolution of biological complexity. Several evolutionary models have been proposed for gene duplication to explain how new gene copies are preserved by natural selection, but these models have rarely been tested using empirical data. Opsin proteins, when combined with a chromophore, form a p...
Quantifying landscape‐level methane fluxes in subarctic Finland using a multiscale approachNARA Subscribed
Quantifying landscape‐scale methane ( CH 4 ) fluxes from boreal and arctic regions, and determining how they are controlled, is critical for predicting the magnitude of any CH 4 emission feedback to climate change. Furthermore, there remains uncertainty regarding the relative importance of small areas of strong methanogenic activity, vs. larger areas with net CH 4 uptake, in controlling landscape‐level fluxes. We measured CH 4...
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