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Functional Activity and Binding Specificity of Small Ankyrin Repeat Proteins Called Ankyrons Against SARS-CoV-2 VariantsNARA Subscribed
Effective management of COVID-19 requires clinical tools to treat the disease in addition to preventive vaccines. Several recombinant mAbs and their cocktails have been developed to treat COVID-19 but these have limitations. Here, we evaluate small ankyrin repeat proteins called Ankyrons that were generated to bind with high affinity to the SARS-CoV-2 virus. Ankyrons are ankyrin repeat proteins comprised of repetitions a struc...
Disentangling the biotic and abiotic drivers of bird–building collisions in a tropical Asian city with ecological niche modelingNARA Subscribed
Bird collisions with buildings are responsible for a large number of bird deaths in cities around the world, yet they remain poorly studied outside North America. We conducted one of the first citywide fine‐scale and landscape‐scale analyses of bird–building collisions in Asia and used maximum entropy modeling (as commonly applied to species distribution modeling) in a novel way to assess the drivers of bird–building collision...
Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding domain (RBD) is a hotspot for mutations, reflecting its critical role at the ACE2 interface during viral entry. Here, we comprehensively investigated the impact of RBD mutations, including 5 variants of concern (VOC) or interest—including Omicron (BA.2)—and 33 common point mutatio...
The cosmopolitan appendicularian Oikopleura dioica reveals hidden genetic diversity around the globeNARA Subscribed
Appendicularian tunicates are some of the most abundant mesozooplankton organisms with key roles in marine trophic webs and global carbon flux. Like most appendicularians with cosmopolitan distributions, Oikopleura dioica Fol, 1872 is considered a single species worldwide based on morphological features that distinguish them from other appendicularians. Despite their abundance, however, there are still only ~ 70 described appe...
Similarity in spatial structure constrains ecosystem relationships: Building a macroscale understanding of lakesNARA Subscribed
Aim We aimed to measure the dominant spatial patterns in ecosystem properties (such as nutrients and measures of primary production) and the multi‐scaled geographical driver variables of these properties and to quantify how the spatial structure of pattern in all of these variables influences the strength of relationships among them. Location and time period We studied > 8,500 lakes in a 1.8 million km 2 area of Northeast U.S....
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