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Natural products as HMG-CoA reductase inhibitors (statins) for the management of non-communicable diseasesNARA Subscribed
Non-communicable diseases, such as diabetes, cancer, as well as cardiovascular, metabolic, and central nervous system disorders stand for significant global health burden. Statins, as HMG-CoA reductase inhibitors, have emerged as a basis in the management of hypercholesterolemia and the prevention of cardiovascular disorders. In this review, we summarize the role of statins in a variety of pathologies, ranging from their well-...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolatesNARA Subscribed
Summary Purpose A series of NDM-producing Escherichia coli ST167 clinical isolates exhibiting resistance to cefiderocol (FDC), with no previous exposure to this antibiotic, were analyzed in this study. Methods The antimicrobial susceptibility testing and phenotypic detection of resistance patterns (Rapid Cefiderocol NP test and MIC determination) were performed for all tested isolates. Their entire genomes were sequenced by us...
Effect of stabilized organic amendments on biodegradability of poly-3-hydroxybutyrate, soil biological properties, and plant biomassNARA Subscribed
Poly-3-hydroxybutyrate (P3HB) is a biodegradable polymer with a potential extensive use in agriculture. However, while P3HB biodegradation boosts microbial enzyme activity, it significantly reduces plant biomass due to nutrient competition. In this study, we test the hypothesis that these detrimental effects can be mitigated though the co-application of nutrient-rich organic amendments, such as compost and digestate. A pot exp...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed