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Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Aging humans and non-human primates both exhibit a similar pattern of cognitive decline beginning in middle age that is characterized by progressive impairments in rule learning, executive function, and working and recognition memory—functions often associated with dysfunction of prefrontal and medial temporal lobe regions. The heterogeneity and inter-subject variability in aging and age-related cognitive impairments present c...
Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect ModelNARA Subscribed
Background: Treatment for nonunion in long bones remains a clinical need. Collagen sponges loaded with recombinant human bone morphogenetic protein 2 (rhBMP-2) are potential grafts but have limited FDA-approved applications due to safety concerns associated with rapid collagen resorption and burst release of rhBMP-2 in vivo . This work investigates keratin proteins obtained from human hair as a potential rhBMP-2 biomaterial ca...