Purpose Antimicrobial peptides show promise as broad-spectrum agents and are less likely to induce rapid resistance. However, protease sensitivity limits their potential as antibiotic alternatives. Non-canonical amino acid incorporation may enhance stability but could impact other properties. Methods The activities of four peptides (oligoarginine (PLR10), oligohomoarginine (PLHR10), Mel4, and Mel4HArg) were tested against stra...