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Human and Porcine Marginal Chordal Forces in a Vacuum Based Physiological In Vitro Mitral Valve ModelNARA Subscribed
Introduction This study aimed to quantitatively investigate the role of marginal chordae of the mitral valve during static closure by analyzing the force within these chordae and its potential correlation with the transvalvular pressure. Materials and Methods Porcine (n = 10) and human (n = 4) mitral valves were mounted in a saddle-shaped annulus clamp, while an in vitro system was utilized to replicate a physiological systoli...
Sequence analysis of a viral strain isolated for the first time in the UK, clarifies the identity of a novel species of fabavirusNARA Subscribed
For the first time sequence data of a fabavirus was identified in dahlia from the UK, which was similar to virus sequence reported from dahlia in China. Initial sequences were determined by high-throughput sequencing (HTS) using the Illumina MiSeq platform, and were verified by Sanger sequencing and 5’ and 3’ rapid amplification of cDNA ends (RACE) polymerase chain reaction (PCR). The genome comprised two RNAs that were 5,851...
Optimizing a Hematology/Oncology Curriculum for Internal Medicine Residents: A Two-Institution Modified Delphi StudyNARA Subscribed
Purpose. Although hematology/oncology (H/O) topics are essential for clinicians, many internal medicine (IM) residents perceive inadequate H/O education. This perception may be due to the lack of a standardized H/O curriculum. To address this gap, we aimed to achieve consensus about the most important H/O topics for IM residents to learn. Methods. In 2023, we conducted a 2-round modified Delphi study of IM generalists and H/O...
Population Genomics of a Cosmopolitan Weed Provides Insights Into Its Local Adaptation and Recent Demographic HistoryNARA Subscribed
Invasive plant species present a growing ecological and economic challenge, and often adapt rapidly to their novel environments through complex demographic and evolutionary processes. Invasion genomics offers powerful tools to disentangle these processes, but most studies rely on geographically narrow sampling across native and non‐native ranges. Erigeron canadensis is a cosmopolitan weed native to North America that has succe...
Assessment of the Orbit® subretinal delivery system (Orbit® SDS device) and prototypes in adult and juvenile canine eyesNARA Subscribed
This study aimed to assess the applicability of the Orbit ® Subretinal Delivery System [Orbit ® SDS, 2nd Generation, clinical-grade device] and prototypes for subretinal injection (SRI) in dogs of different ages. Following ex vivo and in vivo testing of the clinical grade Orbit ® SDS in 7 adult canine eyes, 8 normal dogs (13 eyes; age range: 10–72 weeks) were injected with an AAV2/5-CBA-tdTomato-WPRE vector using different Orb...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...